DISEASES

Disease-gene associations mined from literature

Literature associating LYPD6B and nicotine dependence

LYPD6B [ENSP00000387077]

Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha- 5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing

Synonyms:  LYPD6B,  LYPD6Bp,  hLYPD6B,  F8WB42,  F8WCH4 ...

Linkouts:  STRING  Pharos  UniProt