DISEASES

Disease-gene associations mined from literature

Literature associating CWC22 and melanomatosis

CWC22 [ENSP00000387006]

Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay; Belongs to the CWC22 family.

Synonyms:  CWC22,  CWC22p,  hCWC22,  B7WP74,  Q9HCG8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM