DISEASES

Disease-gene associations mined from literature

Literature associating ITGA6 and junctional epidermolysis bullosa non-Herlitz type

ITGA6 [ENSP00000386896]

CD49 antigen-like family member F; Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.

Synonyms:  ITGA6,  ITGA6p,  hITGA6,  C9JXX7,  H7BZ97 ...

Linkouts:  STRING  Pharos  UniProt  OMIM