DISEASES

Disease-gene associations mined from literature

Literature associating ZC3H8 and retinitis pigmentosa 38

ZC3H8 [ENSP00000386488]

Zinc finger CCCH domain-containing protein 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis; Zinc fingers CCCH-type

Synonyms:  ZC3H8,  ZC3H8p,  hZC3H8,  LOC84524,  Q53QC9 ...

Linkouts:  STRING  Pharos  UniProt