DISEASES

Disease-gene associations mined from literature

Literature associating IL1R1 and cellulitis

IL1R1 [ENSP00000386380]

CD121 antigen-like family member A; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Synonyms:  IL1R1,  IL1R1p,  hIL1R1,  B8ZZ73,  B8ZZW4 ...

Linkouts:  STRING  Pharos  UniProt