Disease-gene associations mined from literature

Literature associating SCN9A and interstitial cystitis

SCN9A [ENSP00000386306]

Sodium channel, voltage-gated, type IX, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain; Sodium voltage-gated channel alpha subunits

Synonyms:  SCN9A,  SCN9Ap,  hSCN9A,  E9PBA5,  H7C064 ...

Linkouts:  STRING  Pharos  UniProt  OMIM