Literature associating SCN9A and trigeminal neuralgia
Sodium channel, voltage-gated, type IX, alpha subunit; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain; Sodium voltage-gated channel alpha subunits
Synonyms: SCN9A, SCN9Ap, hSCN9A, E9PBA5, H7C064 ...