DISEASES

Disease-gene associations mined from literature

Literature associating FOXO3 and rhabdomyosarcoma

FOXO3 [ENSP00000385824]

Forkhead in rhabdomyosarcoma-like 1; Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation; Forkhead boxes

Synonyms:  FOXO3,  FOXO3p,  hFOXO3,  B4DVZ6,  O43524 ...

Linkouts:  STRING  Pharos  UniProt