DISEASES

Disease-gene associations mined from literature

Literature associating MAD1L1 and prostate cancer

MAD1L1 [ENSP00000385334]

Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Synonyms:  MAD1L1,  MAD1L1p,  hMAD1L1,  B3KR41,  C9J9H5 ...

Linkouts:  STRING  Pharos  UniProt