Literature associating CDKN1A and skin melanoma
Cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
Synonyms: CDKN1A, CDKN1Ap, hCDKN1A, A0A024RCX5, J3KQV0 ...