DISEASES

Disease-gene associations mined from literature

Literature associating CDKN1A and cervical adenocarcinoma

CDKN1A [ENSP00000384849]

Cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.

Synonyms:  CDKN1A,  CDKN1Ap,  hCDKN1A,  A0A024RCX5,  J3KQV0 ...

Linkouts:  STRING  Pharos  UniProt