DISEASES

Disease-gene associations mined from literature

Literature associating PARG and autosomal recessive hypercholesterolemia

PARG [ENSP00000384408]

Poly (ADP-ribose) glycohydrolase; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers. Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR- dependent gene promoters. Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.

Synonyms:  PARG,  PARGP1,  B4DHS4,  B4DX76,  PARGP1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM