Literature associating CRLF2 and Down syndrome
Thymic stromal lymphopoietin protein receptor; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system; Belongs to the type I cytokine receptor family. Type 5 subfamily.
Synonyms: CRLF2, CRLF2p, hCRLF2, D0E2W4, J3QKD1 ...