DISEASES

Disease-gene associations mined from literature

Literature associating PLA2G2A and pancreatitis

PLA2G2A [ENSP00000383364]

Phospholipase A2, group IIA (platelets, synovial fluid); Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner; Belongs to the phospholipase A2 family.

Synonyms:  PLA2G2A,  PLA2G2Ap,  hPLA2G2A,  A0A024RA96,  P14555 ...

Linkouts:  STRING  Pharos  UniProt