Literature associating PLA2G2A and orange allergy
PLA2G2A [ENSP00000383364]
Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides . Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 . Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 . Induces cell proliferation in an integrin-dependent manner .
Synonyms: PLA2G2A, PLA2G2Ap, hPLA2G2A, A0A024RA96, A0A3B3IRX2 ...