DISEASES

Disease-gene associations mined from literature

Literature associating SIRPA and vertebrobasilar insufficiency

SIRPA [ENSP00000382941]

Brain Ig-like molecule with tyrosine-based activation motifs; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells; C1-set domain containing

Synonyms:  SIRPA,  B4DP97,  P78324,  B4DP97p,  hB4DP97 ...

Linkouts:  STRING  Pharos  UniProt