Disease-gene associations mined from literature

Literature associating MAP3K1 and chondrodysplasia-pseudohermaphroditism syndrome

MAP3K1 [ENSP00000382423]

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF- kappa-B pathway.

Synonyms:  MAP3K1,  MAP3K1p,  hMAP3K1,  MAP3K1-001,  MAP3K1-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM