Literature associating DYRK1A and Down syndrome
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Synonyms: DYRK1A, DYRK1Ap, hDYRK1A, DYRK1A_VAR1, E7EMI5 ...