Literature associating PARP3 and arthrogryposis, renal dysfunction, and cholestasis 1
ADP-ribosyltransferase diphtheria toxin-like 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing; Poly(ADP-ribose) polymerases
Synonyms: PARP3, PARP3p, hPARP3, A0A024R2X5, F8WAY7 ...