DISEASES

Disease-gene associations mined from literature

Literature associating CABIN1 and acute kidney tubular necrosis

CABIN1 [ENSP00000381364]

Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.

Synonyms:  CABIN1,  CABIN1p,  hCABIN1,  A0A024R1E5,  B5MEB3 ...

Linkouts:  STRING  Pharos  UniProt