DISEASES

Disease-gene associations mined from literature

Literature associating BCL2 and lymphocytic leukemia

BCL2 [ENSP00000381185]

Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release; BCL2 family

Synonyms:  BCL2p,  hBCL2,  A0A024R2B3,  A0A024R2C4,  P10415 ...

Linkouts:  STRING  Pharos  UniProt