DISEASES

Disease-gene associations mined from literature

Literature associating WEE2 and Western equine encephalitis

WEE2 [ENSP00000380675]

Wee1-like protein kinase 1B; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).

Synonyms:  WEE2,  WEE2p,  hWEE2,  P0C1S8,  P0C1S8p ...

Linkouts:  STRING  Pharos  UniProt  OMIM