DISEASES

Disease-gene associations mined from literature

Literature associating NOXO1 and lung mucoepidermoid carcinoma

NOXO1 [ENSP00000380450]

SH3 and PX domain-containing protein 5; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.

Synonyms:  NOXO1,  NOXO1p,  hNOXO1,  H3BN18,  Q8NFA2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM