DISEASES

Disease-gene associations mined from literature

Literature associating CARD11 and central nervous system hematologic cancer

CARD11 [ENSP00000380150]

Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway; CBM complex

Synonyms:  CARD11,  CARD11p,  hCARD11,  A0A024R854,  E2QRC0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM