DISEASES

Disease-gene associations mined from literature

Literature associating ILK and focal segmental glomerulosclerosis

ILK [ENSP00000379975]

59 kDa serine/threonine-protein kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage- dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Synonyms:  ILK,  B7Z1I0,  E9PQ27,  E9PQ52,  HEL-S-28 ...

Linkouts:  STRING  Pharos  UniProt