Literature associating UMOD and chronic kidney disease
Tamm-Horsfall urinary glycoprotein; Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
Synonyms: UMOD, B3KXM9, I3L1A9, I3L1M3, I3L2J2 ...