Literature associating TNRC6A and autosomal recessive chronic granulomatous disease cytochrome b-positive type III
Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes; Belongs to the GW182 family.
Synonyms: TNRC6A, LOC102724266, TNRC6Ap, hTNRC6A, G8JLL8 ...