DISEASES

Disease-gene associations mined from literature

Literature associating SIN3A and autosomal dominant non-syndromic intellectual disability 13

SIN3A [ENSP00000378402]

SIN3 transcription regulator family member A; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).

Synonyms:  SIN3A,  SIN3Ap,  hSIN3A,  H3BNA0,  H3BNZ3 ...

Linkouts:  STRING  Pharos  UniProt