Disease-gene associations mined from literature

Literature associating PPP2R2B and cerebellar ataxia type 9

PPP2R2B [ENSP00000377936]

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity).

Synonyms:  PPP2R2B,  PPP2R2Bp,  hPPP2R2B,  D6RB57,  D6RF04 ...

Linkouts:  STRING  Pharos  UniProt