Literature associating FOLR1 and myelomeningocele
Ovarian tumor-associated antigen MOv18; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Synonyms: FOLR1, FOLR1p, hFOLR1, A0A024R5H1, FOLR1-001 ...