DISEASES

Disease-gene associations mined from literature

Literature associating IL36RN and pustulosis of palm and sole

IL36RN [ENSP00000376896]

Interleukin-1 receptor antagonist homolog 1; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

Synonyms:  IL36RN,  IL36RNp,  hIL36RN,  A0A024R518,  C9JTH1 ...

Linkouts:  STRING  Pharos  UniProt