DISEASES

Disease-gene associations mined from literature

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Literature associating NME1-NME2 and nemaline myopathy 2

NME1-NME2 [ENSP00000376886]

C-myc purine-binding transcription factor PUF; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Exhibits histidine protein kinase activity.

Synonyms:  NME1-NME2,  NME2,  NM23B,  NM23-LV,  NME2p ...

Linkouts:  STRING  Pharos  OMIM

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.