Literature associating STEAP3 and hypochromic microcytic anemia
Six-transmembrane epithelial antigen of prostate 3; Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP; STEAP family
Synonyms: STEAP3, STEAP3p, hSTEAP3, A0A024RAD7, B8ZZX6 ...