DISEASES

Disease-gene associations mined from literature

Literature associating MLF1 and small intestine neuroendocrine neoplasm

MLF1 [ENSP00000376568]

Myelodysplasia-myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus; Belongs to the MLF family.

Synonyms:  MLF1,  MLF1p,  hMLF1,  C9J3M3,  C9JNE5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM