Disease-gene associations mined from literature

Literature associating TMEM119 and lesion of sciatic nerve

TMEM119 [ENSP00000376553]

Osteoblast induction factor; Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).

Synonyms:  TMEM119,  TMEM119p,  hTMEM119,  F8VS22,  F8VZL0 ...

Linkouts:  STRING  Pharos  UniProt