Disease-gene associations mined from literature

Literature associating TIRAP and cerebral malaria

TIRAP [ENSP00000376445]

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6; TIR domain containing

Synonyms:  TIRAP,  A0A024R3M4,  F5H2K1,  P58753,  F5H2K1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM