Disease-gene associations mined from literature

Literature associating WASF1 and substance dependence

WASF1 [ENSP00000376368]

Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity); A-kinase anchoring proteins

Synonyms:  WASF1,  WASF1p,  hWASF1,  Q5SZK3,  Q5SZK4 ...

Linkouts:  STRING  Pharos  UniProt