DISEASES

Disease-gene associations mined from literature

Literature associating CIT and primary autosomal recessive microcephaly

CIT [ENSP00000376306]

Citron rho-interacting serine/threonine kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.

Synonyms:  CIT,  F5H4K4,  H0YGG8,  O14578,  CRIK ...

Linkouts:  STRING  Pharos  UniProt  OMIM