DISEASES

Disease-gene associations mined from literature

Literature associating CARD8 and Masters-Allen syndrome

CARD8 [ENSP00000375767]

Tumor up-regulated CARD-containing antagonist of CASP9; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases; Caspase recruitment domain containing

Synonyms:  CARD8,  CARD8p,  hCARD8,  CARD8-001,  CARD8-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM