DISEASES

Disease-gene associations mined from literature

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Literature associating CCDC88C and cerebral degeneration

CCDC88C [ENSP00000374507]

Dvl-associating protein with a high frequency of leucine residues; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family.

Synonyms:  CCDC88C,  CCDC88Cp,  hCCDC88C,  B4DZB8,  CCDC88C-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.