DISEASES

Disease-gene associations mined from literature

Literature associating DCP2 and cleft palate

DCP2 [ENSP00000373715]

Nucleoside diphosphate-linked moiety X motif 20; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts; Nudix hydrolase family

Synonyms:  DCP2,  DCP2p,  hDCP2,  B7Z3U5,  D6RCL0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM