DISEASES

Disease-gene associations mined from literature

Literature associating NELFA and Wolf-Hirschhorn syndrome

NELFA [ENSP00000372335]

Wolf-Hirschhorn syndrome candidate 2 protein; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. In vitro, the NELFA:NELFCD subcomplex binds to ssDNA and ssRNA in a sequence- and structure-dependent manner. Probably required to interact with the RNA polymerase II complex.

Synonyms:  B3KSP0,  C9JEM7,  C9JHL4,  F8W954,  F8WF98 ...

Linkouts:  STRING  Pharos  UniProt