Literature associating IGF2BP2 and Wolfram syndrome
Insulin-like growth factor 2 mRNA binding protein 2; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts; Belongs to the RRM IMP/VICKZ family.
Synonyms: IGF2BP2, IGF2BP2p, hIGF2BP2, F8W930, IGF2BP2-001 ...