DISEASES

Disease-gene associations mined from literature

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Literature associating DNAJC21 and autosomal dominant severe congenital neutropenia

DNAJC21 [ENSP00000371451]

DnaJ (Hsp40) homolog, subfamily C, member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins

Synonyms:  DNAJC21,  DNAJC21p,  hDNAJC21,  Q5F1R6,  DNAJA5 ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.