Disease-gene associations mined from literature

Literature associating CD274 and oropharynx cancer

CD274 [ENSP00000370989]

Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self . As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response . Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) .

Synonyms:  CD274,  CD274p,  hCD274,  Q9NZQ7,  Q9NZQ7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM