DISEASES

Disease-gene associations mined from literature

Literature associating IL33 and allergic contact dermatitis

IL33 [ENSP00000370842]

Nuclear factor from high endothelial venules; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury; Interleukins

Synonyms:  IL33,  IL33p,  hIL33,  O95760,  C9orf26 ...

Linkouts:  STRING  Pharos  UniProt  OMIM