Literature associating IGFBP3 and Sotos syndrome
Insulin-like growth factor binding protein 3; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Synonyms: IGFBP3, IGFBP3p, hIGFBP3, A6XND0, A6XND1 ...