DISEASES

Disease-gene associations mined from literature

Literature associating IRF4 and central nervous system hematologic cancer

IRF4 [ENSP00000370343]

Lymphocyte-specific interferon regulatory factor; Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).

Synonyms:  IRF4,  IRF4p,  hIRF4,  F2Z3D5,  Q15306 ...

Linkouts:  STRING  Pharos  UniProt  OMIM