Literature associating NKX3-1 and prostate disease
Homeobox protein NK-3 homolog A; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells; Belongs to the NK-3 homeobox family.
Synonyms: NKX3-1, Q99801, NKX3.1, NKX3A, Q99801p ...