Literature associating WRNIP1 and spastic monoplegia
Werner helicase interacting protein 1; Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS; AAA ATPases
Synonyms: WRNIP1, WRNIP1p, hWRNIP1, Q96S55, Q96S55p ...